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Papers of the Week

2020 Mar

Reg Anesth Pain Med



Levocorydalmine attenuates microglia activation and neuropathic pain by suppressing ASK1-p38 MAPK/NF-κB signaling pathways in rat spinal cord.


Dai W-L, Bao Y-N, Fan J-F, Li S-S, Zhao W-L, Yu B-Y, Liu J-H
Reg Anesth Pain Med. 2020 Mar; 45(3):219-229.
PMID: 31898581.


Neuropathic pain is partially refractory to currently available treatments. Although some studies have reported that apoptosis signal-regulating kinase 1 (ASK1) may inhibit chronic pain, the mechanisms underlying this process have not been fully elucidated.