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Papers of the Week

2020 Mar

World Neurosurg


Intracranial Low-grade Fibromyxoid Sarcoma: Findings on Electron Microscopy and Histological Analysis.


Shimizu Y, Tsuchiya K, Fujisawa H
World Neurosurg. 2020 Mar; 135:301-305.
PMID: 31899392.


Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor presenting as a deep soft-tissue mass characterized by a benign histology, but with potentially aggressive clinical behavior and a high rate of recurrence; primary intracranial sarcomas are even rarer. Here, we present a case of primary intracranial LGFMS, emphasizing its clinical, radiological, and histological features. A 39 -year-old woman presented with a recent history of headache and seizures. A right parietal mass was detected on computed tomography and magnetic resonance imaging, and she was subsequently operated upon to remove the intracranial mass. Histological examination of the resected tumor revealed mildly atypical fibroblastic cells embedded within a myxoid matrix. The diagnosis was confirmed by electron microscopy and cytogenetic analyses. This report is the first electron microscopic evaluation of intracranial LGFMS, which has an extremely rare occurrence.