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Papers of the Week

Papers: 28 Dec 2019 - 3 Jan 2020

Human Studies

2019 12 31

Clin Epigenetics



Transient receptor potential ankyrin 1 promoter methylation and peripheral pain sensitivity in Crohn’s disease.


Gombert S, Rhein M, Winterpacht A, Münster T, Hillemacher T, Leffler A, Frieling H
Clin Epigenetics. 2019 12 31; 12(1):1.
PMID: 31892361.


Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract associated with abdominal pain and diarrhea. Pain caused by Crohn's disease likely involves neurogenic inflammation which seems to involve the ion channel transient receptor potential ankyrin 1 (TRPA1). Since the promoter methylation of TRPA1 was shown to influence pain sensitivity, we asked if the expression of TRPA1 is dysregulated in patients suffering from Crohn's disease. The methylation rates of CpG dinucleotides in the TRPA1 promoter region were determined from DNA derived from whole blood samples of Crohn patients and healthy participants. Quantitative sensory testing was used to examine pain sensitivities.