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Papers of the Week

Papers: 28 Dec 2019 - 3 Jan 2020

2020 Apr

Eur J Pain



Von Frey testing revisited – provision of an online algorithm for improved accuracy of 50% thresholds.


Christensen SL, Hansen RB, Storm MA, Olesen J, Hansen TF, Ossipov M, Izarzugaza JMG, Porreca F, Kristensen DM
Eur J Pain. 2020 Apr; 24(4):783-790.
PMID: 31889375.


In the pain field, it is essential to quantify nociceptive responses. The response to the application of von Frey filaments to the skin measures tactile sensitivity and is a surrogate marker of allodynia in states of peripheral and/or central sensitization. The method is widely used across species within the pain field. However, uncertainties appear to exist regarding the appropriate method for analysing obtained data. Therefore, there is a need for refinement of the calculations for transformation of raw data to quantifiable data.