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Papers of the Week

Papers: 28 Dec 2019 - 3 Jan 2020

2019 12 27

Syst Rev



Magnetic resonance spectroscopy across chronic pain disorders: a systematic review protocol synthesising anatomical and metabolite findings in chronic pain patients.


Levins KJ, Drago T, Roman E, Martin A, King R, Murphy P, Gallagher H, Barry D, O'Hanlon E, Roddy D W
Syst Rev. 2019 12 27; 8(1):338.
PMID: 31882014.


Chronic pain is pain greater than 3 months duration that may result from disease, trauma, surgery, or unknown origin. The overlap between the psychological, behavioural, and management aspects of pain suggest that limbic brain neurochemistry plays a role in chronic pain pathology. Proton magnetic resonance spectroscopy (H-MRS) can evaluate in vivo brain metabolites including creatine, N-acetylaspartate, myo-inositol, choline, glutamate, glutamine, and gamma-aminobutyric acid in chronic pain; however, a comprehensive systemic review of metabolite expression patterns across all brain areas has yet to be performed.