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Papers of the Week

Papers: 28 Dec 2019 - 3 Jan 2020

Animal Studies


2020 01

Ann Clin Transl Neurol



First FHM3 mouse model shows spontaneous cortical spreading depolarizations.


Jansen NA, Dehghani A, Linssen MML, Breukel C, Tolner EA, van den Maagdenberg AMJM
Ann Clin Transl Neurol. 2020 01; 7(1):132-138.
PMID: 31880072.


Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V-mutated α1 subunits in voltage-gated Na 1.1 sodium channels (Scn1a ). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.