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Papers of the Week

Papers: 21 Dec 2019 - 27 Dec 2019

Human Studies

2020 Apr

Eur J Pain



Temporal aspects of endogenous pain modulation during a noxious stimulus prolonged for one day.


Hoeger Bement M, Petersen KK, Sørensen L B, Andersen HH, Graven-Nielsen T
Eur J Pain. 2020 Apr; 24(4):752-760.
PMID: 31876363.


This study investigated 1) if a prolonged noxious stimulus (24-hr topical capsaicin) in healthy adults would impair central pain inhibitory and facilitatory systems measured as a reduction in conditioned pain modulation (CPM) and enhancement of temporal summation of pain (TSP) and 2) if acute pain relief or exacerbation (cooling and heating the capsaicin patch) during the prolonged noxious stimulus would affect central pain modulation.