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Papers of the Week
Different receptor mechanisms underlying phytocannabinoid- versus synthetic cannabinoid-induced tetrad effects: Opposite roles of CB1/CB2 versus GPR55 receptors.
Abstract
Cannabis or cannabinoids produce characteristic tetrad effects – analgesia, hypothermia, catalepsy, and suppressed locomotion, which are generally believed to be mediated by the activation of cannabinoid CB1 receptors (CB1Rs). Given recent findings of CB2 and GPR55 receptors in the brain, we examined whether CB2 and GPR55 receptors are also involved in cannabinoid action.