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Papers of the Week

Papers: 21 Dec 2019 - 27 Dec 2019

Animal Studies, Pharmacology/Drug Development

2020 Apr

Br J Pharmacol



Different receptor mechanisms underlying phytocannabinoid- versus synthetic cannabinoid-induced tetrad effects: Opposite roles of CB1/CB2 versus GPR55 receptors.


Wang X-F, Galaj E, Bi G-H, Zhang C, He Y, Zhan J, Bauman M, Gardner EL, Xi Z-X
Br J Pharmacol. 2020 Apr; 177(8):1865-1880.
PMID: 31877572.


Cannabis or cannabinoids produce characteristic tetrad effects – analgesia, hypothermia, catalepsy, and suppressed locomotion, which are generally believed to be mediated by the activation of cannabinoid CB1 receptors (CB1Rs). Given recent findings of CB2 and GPR55 receptors in the brain, we examined whether CB2 and GPR55 receptors are also involved in cannabinoid action.