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Papers of the Week


Papers: 21 Dec 2019 - 27 Dec 2019


Animal Studies, Pharmacology/Drug Development


2020 Apr


Br J Pharmacol


177


8

Different receptor mechanisms underlying phytocannabinoid- versus synthetic cannabinoid-induced tetrad effects: Opposite roles of CB1/CB2 versus GPR55 receptors.

Authors

Wang X-F, Galaj E, Bi G-H, Zhang C, He Y, Zhan J, Bauman M, Gardner EL, Xi Z-X
Br J Pharmacol. 2020 Apr; 177(8):1865-1880.
PMID: 31877572.

Abstract

Cannabis or cannabinoids produce characteristic tetrad effects – analgesia, hypothermia, catalepsy, and suppressed locomotion, which are generally believed to be mediated by the activation of cannabinoid CB1 receptors (CB1Rs). Given recent findings of CB2 and GPR55 receptors in the brain, we examined whether CB2 and GPR55 receptors are also involved in cannabinoid action.