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Papers of the Week

Papers: 21 Dec 2019 - 27 Dec 2019

Animal Studies, Pharmacology/Drug Development

2019 Nov

Ann Palliat Med



Intra-amygdala infusion of zeta inhibitory peptide attenuates neuropathic pain but not inflammatory pain in adult rats.


Yao J, Zhang L, Lei W, Huang Y, Zhang H, Lu B, Yao Y, Zhao L, Sun J
Ann Palliat Med. 2019 Nov; 8(5):660-666.
PMID: 31865727.


Protein kinase Mζ (PKMζ), a typical brain-specific PKC isoform, has been shown to be critical in the maintenance of long-term potentiation and memory storage. Zeta inhibitory peptide (ZIP), a peptide with selective inhibition of PKMζ, has been used in relieving experimental neuropathic pain and disrupting memory. The aim of this study was to investigate the effects of intra-amygdalar infusion of ZIP on neuropathic pain induced by chronic constriction injury (CCI), and inflammatory pain induced by complete Freund's adjuvant (CFA) in adult rats.