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Papers of the Week


Papers: 14 Dec 2019 - 20 Dec 2019


Animal Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2020 Apr


Cephalalgia


40


4

Ultra-rapid brain uptake of subcutaneous sumatriptan in the rat: Implication for cluster headache treatment.

Authors

Muzzi M, Zecchi R, Ranieri G, Urru M, Tofani L, De Cesaris F, Panconesi A, Chiarugi A
Cephalalgia. 2020 Apr; 40(4):330-336.
PMID: 31852231.

Abstract

In spite of the substantial therapeutic efficacy of triptans, their site of action is still debated. Subcutaneous sumatriptan is the most efficacious symptomatic treatment for cluster headache (CH) patients, showing therapeutic onset within a few minutes after injection even in migraine patients. However, whether subcutaneous sumatriptan is able to reach the CNS within this short time frame is currently unknown.