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Papers of the Week
Cellular distribution of PACAP-38 and PACAP receptors in the rat brain: Relation to migraine activated regions.
Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) occurs as either a 27- or 38-amino acid neuropeptide and belongs to the vasoactive intestinal polypeptide/glucagon/secretin family of peptides. PACAP and vasoactive intestinal polypeptide have a 68% homology of their amino acid sequences and share three B-type G-protein coupled receptors: VPAC, VPAC and PAC receptors.