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Papers of the Week


2019


J Pain Res


12

Remifentanil-Induced Secondary Hyperalgesia Is Not Prevented By Preoperative Acetazolamide Administration In Patients Undergoing Total Thyroidectomy: A Randomized Controlled Trial.

Authors

Gutiérrez R, Contreras F, Blanch A, Bravo D, Egaña JI, Rappoport D, Cabané P, Rodríguez F, Penna A
J Pain Res. 2019; 12:2991-2997.
PMID: 31807056.

Abstract

Acute administration of remifentanil may lead to opioid-induced hyperalgesia (OIH). Studies in mice suggest that OIH is mediated by impaired anionic homeostasis in spinal lamina I neurons due to a down-regulation of the K-Cl co-transporter KCC2, which was reverted using acetazolamide (ACTZ), a carbonic anhydrase inhibitor. We propose that ACTZ prevents remifentanil-mediated OIH in humans.