I am a
Home I AM A Search Login

Papers of the Week

Papers: 30 Nov 2019 - 6 Dec 2019

Animal Studies, Pharmacology/Drug Development

2020 Feb 01

Brain Res


Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models.


Wagner KM, Atone J, Hammock BD
Brain Res. 2020 Feb 01; 1728:146573.
PMID: 31790682.


Effectively treating chronic pain remains a therapeutic challenge in the clinic. Recent evidence has shown the inhibition of the soluble epoxide hydrolase (sEH) to be an effective strategy to limit chronic pain in preclinical models, horses and companion animals. Determining the safety ofsEH inhibition in addition to this demonstrated efficacy is a critical step to the further development ofsEH inhibitors (sEHI) as analgesics. Here we describe a comparison of thesEHI TPPU with other first in class analgesics for human chronic pain. We assess the development of tolerance to the analgesia mediated by TPPU with extended use. We also assess for CNS effects by measuring changes in motor control and functioning. ThesEHI are multimodal analgesics that have demonstrated potent efficacy against chronic pain. They have previously been tested and show no reward potential using operant methods. The results of the current experiments show that they lack motor function effects and also lack the development of tolerance with extended dosing.