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Papers of the Week

Papers: 30 Nov 2019 - 6 Dec 2019

Human Studies, Pharmacology/Drug Development

2020 Mar




Influence of St. John’s Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial.


Loughren MJ, Kharasch ED, Kelton-Rehkopf MC, Syrjala KL, Shen DD
Anesthesiology. 2020 Mar; 132(3):491-503.
PMID: 31794512.


The popular herbal medicine, St. John's wort, is a potent inducer of several cytochrome P450 enzymes, including CYP3A4, which plays a role in the metabolism of fentanyl. St. John's wort may also influence the expression of P-glycoprotein, which can alter the movement of drugs across the blood-brain barrier.