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Papers: 30 Nov 2019 - 6 Dec 2019
Human Studies, Pharmacology/Drug Development
2020 Mar
Anesthesiology
132
3
The popular herbal medicine, St. John's wort, is a potent inducer of several cytochrome P450 enzymes, including CYP3A4, which plays a role in the metabolism of fentanyl. St. John's wort may also influence the expression of P-glycoprotein, which can alter the movement of drugs across the blood-brain barrier.