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Papers of the Week

Papers: 30 Nov 2019 - 6 Dec 2019

Animal Studies

2020 Jan 15

Brain Res


Loss of endogenous analgesia leads to delayed recovery from incisional pain in a rat model of chronic neuropathic pain.


Ohta J, Suto T, Kato D, Hiroki T, Obata H, Saito S
Brain Res. 2020 Jan 15; 1727:146568.
PMID: 31785233.


Preoperative pain and impaired endogenous analgesia are risk factors of chronic postsurgical persistent pain (CPSP). A Chronic neuropathic pain model induced by spinal nerve ligation (SNL6W) shows impaired endogenous analgesia and delayed recovery from incisional pain. Repeated amitriptyline treatment can restore the endogenous analgesia, but its effects on delayed recovery are not clear.