I am a
Home I AM A Search Login

Papers of the Week

2019 Nov 28

Arthritis Res Ther



Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain.


Cordaro M, Siracusa R, Impellizzeri D, D'Amico R, Peritore A F, Crupi R, Gugliandolo E, Fusco R, Paola R D, Schievano C, Cuzzocrea S
Arthritis Res Ther. 2019 Nov 28; 21(1):254.
PMID: 31779692.


Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to play a key role in orchestrating this detrimental triad. ALIAmides down-modulate mast cells and more generally hyperactive cells. Here we investigated the safety and effectiveness of the ALIAmide N-palmitoyl-D-glucosamine (PGA) in inflammation and osteoarthritis pain.