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Papers of the Week

2019 Nov

Pain Manag



Device review: Pulsante™ sphenopalatine ganglion microstimulator.


Nwazota N, Pyati S, Fisher K, Roy L
Pain Manag. 2019 Nov; 9(6):535-541.
PMID: 31782695.


Cluster headache (CH) is a primary headache disorder. The use of neuromodulation in treatment of CH is well documented. The sphenopalatine ganglion (SPG) has long been a target for management of CH. Intervention at the level of the SPG can interrupt the trigemino-autonomic reflex, which mediates CH pain. The Pulsante system is the only device on the market created for SPG stimulation. The Pulsante device consists of the device body, a lead with six stimulating electrodes placed in the pterygopalatine fossa, and a fixation plate to allow anchoring of the device to the maxilla. Stimulation is administered via a patient-controlled handheld remote control held over the cheek. SPG stimulation is an important treatment option for CH patients.