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Papers of the Week

Papers: 30 Nov 2019 - 6 Dec 2019

Human Studies, Pharmacology/Drug Development

2020 Mar

Eur J Pain



Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study.


Kumar NS, Muktesh G, Samra T, Sharma P, Samanta J, Sinha SK, Dhaka N, Yadav TD, Gupta V, Kochhar R
Eur J Pain. 2020 Mar; 24(3):639-648.
PMID: 31782864.


Opioids and NSAIDs are commonly used for pain relief in AP. Opioids carry risk of sphincter of oddi constriction. Although diclofenac prevents post ERCP pancreatitis, few reports of diclofenac associated AP is also present. Although, both tramadol and diclofenac are commonly used for pain relief in AP, no study has evaluated their comparative efficacy and safety.