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Papers of the Week

Papers: 23 Nov 2019 - 29 Nov 2019

Human Studies, Pharmacology/Drug Development

2019 Dec




Editor's Pick

Analgesic and Respiratory Depressant Effects of R-dihydroetorphine: A Pharmacokinetic-Pharmacodynamic Analysis in Healthy Male Volunteers.


Olofsen E, Boom M, Sarton E, van Velzen M, Baily P, Smith KJ, Oksche A, Dahan A, Niesters M
Anesthesiology. 2019 Dec; 131(6):1327-1339.
PMID: 31651529.


There is an ongoing need for potent opioids with less adverse effects than commonly used opioids. R-dihydroetorphine is a full opioid receptor agonist with relatively high affinity at the μ-, δ- and κ-opioid receptors and low affinity at the nociception/orphanin FQ receptor. The authors quantified its antinociceptive and respiratory effects in healthy volunteers. The authors hypothesized that given its receptor profile, R-dihydroetorphine will exhibit an apparent plateau in respiratory depression, but not in antinociception.