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Papers of the Week

Papers: 23 Nov 2019 - 29 Nov 2019

Human Studies

2020 Jul




Fiber Threshold Accommodation as a Mechanism of Burst and High-Frequency Spinal Cord Stimulation.


Arle JE, Mei L, Carlson KW
Neuromodulation. 2020 Jul; 23(5):582-593.
PMID: 31774232.


Burst and high-frequency spinal cord stimulation (SCS), in contrast to low-frequency stimulation (LFS, < 200 Hz), reduce neuropathic pain without the side effect of paresthesia, yet it is unknown whether these methods' mechanisms of action (MoA) overlap. We used empirically based computational models of fiber threshold accommodation to examine the three MoA.