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Papers of the Week

Papers: 23 Nov 2019 - 29 Nov 2019

Human Studies

2019 Dec

Contemp Clin Trials Commun


Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design.


Nikles J, Tate RL, Mitchell G, Perdices M, McGree JM, Freeman C, Jacob S, Taing MW, Sterling M
Contemp Clin Trials Commun. 2019 Dec; 16:100480.
PMID: 31763492.


Whiplash associated disorder (WAD), a common and disabling condition, incurs huge burden and costs to Australia. Yet, current treatments for whiplash are not very effective; improved outcomes are urgently needed. Clinical guidelines recommend simple analgesia (paracetamol and non-steroidal anti-inflammatory drugs) but there have been no trials of guideline-recommended drugs. This study will investigate the effectiveness of evidence-based advice (EBA), paracetamol, naproxen, and both paracetamol and naproxen, in reducing daily neck pain and preventing chronic neck pain after whiplash injury.