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Papers of the Week

Papers: 23 Nov 2019 - 29 Nov 2019

Pharmacology/Drug Development


2020 Mar

J Pain Palliat Care Pharmacother



Calcitonin Gene-Related Peptide (CGRP) Antagonists and Their Use in Migraines.


Henson B, Hollingsworth H, Nevois E, Herndon C
J Pain Palliat Care Pharmacother. 2020 Mar; 34(1):22-31.
PMID: 31763951.


Migraine is highly prevalent and associated with a large socio-economic burden in the United States. Current preventive medications have variable efficacy and their use is often limited by intolerable side effects. Calcitonin gene-related peptide (CGRP) has been identified as an integral part of migraine pathophysiology. There are currently seven CGRP antagonists under investigation, all of which are undergoing or have completed phase 3 clinical trials. Three of the investigated CGRP antagonists are approved for use within and outside of the United States. The trials have resulted in positive efficacy and safety data. The purpose of this review is to evaluate the seven CGRP antagonists and their future place in therapy.