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Papers of the Week

2020 Apr 15

Clin Cancer Res



Pre-operative β-blockade with propranolol reduces biomarkers of metastasis in breast cancer: a Phase II randomized trial.


Hiller JG, Cole SW, Crone EM, Byrne DJ, Shackleford DM, Pang J-MB, Henderson MA, Nightingale SS, Ho KM, Myles PS, Fox S, Riedel B, Sloan EK
Clin Cancer Res. 2020 Apr 15; 26(8):1803-1811.
PMID: 31754048.


The majority of deaths from breast cancer occur following the development of metastatic disease, a process inhibited by β-blockers in pre-clinical studies. This phase II randomized controlled trial evaluated the effect of pre-operative β-blockade with propranolol on biomarkers of metastatic potential and the immune cell profile within the primary tumor of patients with breast cancer.