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Papers of the Week

2020 Jan 01

Life Sci


Low-tidal-volume prevent ventilation induced inflammation in a mouse model of sepsis.


Boehm O, Rohner M, Ehrentraut H, Günther U, Meyer R, Knuefermann P, Baumgarten G, Duerr G D, Velten M
Life Sci. 2020 Jan 01; 240:117081.
PMID: 31756342.


Pulmonary inflammation, increased vascular permeability, and pulmonary edema, occur in response to primary pulmonary infections like pneumonia but are also evident in endotoxemia or sepsis. Mechanical ventilation augments pre-existing lung injury and inflammation resulting from exposure to microbial products. The objective of this study was to test the hypothesis that low-tidal-volume prevent ventilation induced lung injury in sepsis.