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Papers of the Week

Papers: 16 Nov 2019 - 22 Nov 2019

Human Studies

2020 May

Arthritis Rheumatol



Heritability of the fibromyalgia phenotype varies by age.


Dutta D, Brummett CM, Moser SE, Fritsche LG, Tsodikov A, Lee S G, Clauw DJ, Scott LJ
Arthritis Rheumatol. 2020 May; 72(5):815-823.
PMID: 31736264.


Many studies suggest a strong familial component to fibromyalgia (FM). However, these studies have nearly all been confined to individuals with "primary" FM, i.e. FM without any other accompanying disorder. The current 2011-16 criteria for diagnosing FM construct a score using a combination of the number of painful body sites and the severity of somatic symptoms (FM-score). We estimated the genetic heritability of FM-score across sex and age groups to identify subgroups of individuals with greater heritability, which may help in the design of future genetic studies.