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Papers of the Week

2019 Dec

Clin Ther



Perioperative Opioid-Sparing Strategies: Utility of Conventional NSAIDs in Adults.


Martinez L, Ekman E, Nakhla N
Clin Ther. 2019 Dec; 41(12):2612-2628.
PMID: 31733939.


Opioids have long been used to treat acute postsurgical and postprocedural pain; however, opioid-related adverse events (AEs) contribute to poor patient outcomes. In addition, perisurgical exposure to opioids can potentially increase the risk for opioid-use disorder. NSAIDs reduce pain and inflammation by a mechanism different from that of opioid analgesics and may be useful in reducing the need for opioid drugs as part of a multimodal analgesia strategy. We conducted this review to assess the effectiveness and tolerability of adjunctive conventional NSAIDs given systemically in the perioperative setting in terms of opioid-sparing effects observed postoperatively.