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Papers of the Week

2020 May

Osteoarthritis Cartilage



Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors.


Sharma N, Drobinski P, Kayed A, Chen Z, Kjelgaard-Petersen CF, Gantzel T, Karsdal MA, Michaelis M, Ladel C, Bay-Jensen A-C, Lindemann S, Thudium CS
Osteoarthritis Cartilage. 2020 May; 28(5):658-668.
PMID: 31734268.


Links between pain and joint degradation are poorly understood. We investigated the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and maintaining the inflammatory loop in OA causing joint destruction.