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Papers of the Week

Papers: 16 Nov 2019 - 22 Nov 2019

Animal Studies, Pharmacology/Drug Development

2020 Apr

Br J Pharmacol



Acetaminophen, a centrally-acting analgesic involving the periaqueductal grey.


Barrière D A, Boumezbeur F, Dalman R, Cadeddu R, Richard D, Pinguet J, Daulhac L, Sarret P, Whittingstall K, Keller M, Mériaux S, Eschalier A, Mallet C
Br J Pharmacol. 2020 Apr; 177(8):1773-1792.
PMID: 31734950.


We previously demonstrated that acetaminophen (AcAP) has to be metabolized in the brain by fatty acid amide hydrolase enzyme (FAAH) into AM404 (N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide) to recruit CB1 and TRPV1 receptors, responsible for its analgesic effect. However, the brain mechanisms supporting AcAP-induced analgesia remain unknown.