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Papers of the Week

Papers: 16 Nov 2019 - 22 Nov 2019

Animal Studies, Pharmacology/Drug Development

2020 Apr

Br J Pharmacol



Novel neuroactive steroid with hypnotic and T-channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain.


Joksimovic S L, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM
Br J Pharmacol. 2020 Apr; 177(8):1735-1753.
PMID: 31732978.


Neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) is a novel hypnotic and voltage-dependent blocker of T-type calcium channels. Here we examine its potential analgesic effects and adjuvant anesthetic properties using a post-surgical pain model in rodents.