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Papers of the Week

2020 Apr

Prostaglandins Other Lipid Mediat


Role of sphingolipids in the pathogenesis of intrahepatic cholestasis.


Mikucka-Niczyporuk A, Pierzynski P, Lemancewicz A, Kosinski P, Charkiewicz K, Knas M, Kacerovsky M, Blachnio-Zabielska A, Laudanski P
Prostaglandins Other Lipid Mediat. 2020 Apr; 147:106399.
PMID: 31733339.


Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disorder that affects from 0.2% to 15.6% pregnant women. The disease is connected with increased risk of fetal morbidity and mortality, but is unfortunately detected quite late. The diagnosis of ICP is based on only one manifestation: pruritus which mainly affects soles and palms.