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Papers of the Week

Papers: 9 Nov 2019 - 15 Nov 2019


Human Studies

2019 Nov 11

BMJ Open



Relieving acute pain (RAP) study: a proof-of-concept protocol for a randomised, double-blind, placebo-controlled trial.


Colloca L, Lee S E, Luhowy M N, Haycock N, Okusogu C, Yim S, Raghuraman N, Goodfellow R, Murray R S, Casper P, Lee M, Scalea T, Fouche Y, Murthi S
BMJ Open. 2019 Nov 11; 9(11):e030623.
PMID: 31719077.


Physicians and other prescribing clinicians use opioids as the primary method of pain management after traumatic injury, despite growing recognition of the major risks associated with usage for chronic pain. Placebos given after repeated administration of active treatments can acquire medication-like effects based on learning mechanisms. This study hypothesises that dose-extending placebos can be an effective treatment in relieving clinical acute pain in trauma patients who take opioids.