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Papers of the Week

Papers: 9 Nov 2019 - 15 Nov 2019

Animal Studies, Pharmacology/Drug Development

2021 May

Br J Pharmacol



The nociceptin/orphaninFQ receptor system as a target to alleviate cancer-induced bone pain in rats: Model validation and pharmacological evaluation.


Sliepen SHJ, Korioth J, Christoph T, Tzschentke TM, Diaz-delCastillo M, Heegaard A-M, Rutten K
Br J Pharmacol. 2021 May; 178(9):1995-2007.
PMID: 31724155.


Cancer-induced bone pain remains inadequately controlled and current standard of care analgesics are accompanied by several side effects. Nociceptin/orphanin FQ peptide (NOP) receptor agonists have demonstrated broad analgesic properties in rodent neuropathic and inflammatory pain models. Here, we investigate the analgesic potential of NOP receptor activation in a rodent cancer-induced bone pain model.