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Papers of the Week

Papers: 9 Nov 2019 - 15 Nov 2019

Human Studies


2020 Oct 01

Cardiovasc Res



Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine.


Staehr C, Rajanathan R, Postnov DD, Hangaard L, Bouzinova EV, Lykke-Hartmann K, Bach FW, Sandow SL, Aalkjaer C, Matchkov VV
Cardiovasc Res. 2020 Oct 01; 116(12):2009-2020.
PMID: 31710670.


Acute migraine attack in familial hemiplegic migraine type 2 (FHM2) patients is characterized by sequential hypo- and hyperperfusion. FHM2 is associated with mutations in the Na,K-ATPase α2 isoform. Heterozygous mice bearing one of these mutations (α2+/G301R) were shown to have elevated cerebrovascular tone and, thus, hypoperfusion that might lead to elevated concentrations of local metabolites. We hypothesize that these α2+/G301R mice also have increased cerebrovascular hyperemic responses to these local metabolites leading to hyperperfusion in the affected part of the brain.