I am a
Home I AM A Search Login

Papers of the Week

Papers: 9 Nov 2019 - 15 Nov 2019

Human Studies

2020 May 01

Pain Med



An Explorative Study of CYP2D6’s Polymorphism in a Sample of Chronic Pain Patients.


Fanelli A, Palazzo C, Balzani E, Iuvaro A, Pelotti S, Melotti R M
Pain Med. 2020 May 01; 21(5):1010-1017.
PMID: 31710684.


A proper antalgic treatment is based on the use of titrated drugs to provide adequate relief and a good tolerability profile. Therapies have a variable effectiveness among subjects depending on medical and genetic conditions. CYP2D6 variations determine a different clinical response to most analgesic drugs commonly used in daily clinical practice by influencing the drugs' pharmacokinetics. This study was a monocentric clinical trial exploring the CYP2D6 variants in 100 patients with a diagnosis of chronic pain.