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Papers of the Week

2019 Nov 08

J Immunother Cancer



Guillain-Barre syndrome observed with adoptive transfer of lymphocytes genetically engineered with an NY-ESO-1 reactive T-cell receptor.


Joseph J, Nathenson MJ, Trinh V A, Malik K, Nowell E, Carter K, Weathers S-P, Demetri GD, Araujo D, Conley AP
J Immunother Cancer. 2019 Nov 08; 7(1):296.
PMID: 31703609.


Adoptive transfer of autologous T-lymphocytes transduced with a high affinity NY-ESO-1-reactive T-cell receptor (NY-ESO-1 T-cells) has emerged as a promising therapeutic strategy for patients with refractory synovial sarcoma. Secondary autoimmune T-cell mediated toxicities can occur long after initial adoptive T-cell transfer. We report on the first two cases of the development and management of Guillain-Barre syndrome in synovial sarcoma patients who received NY-ESO-1 T-cells.