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Papers of the Week

2020 Feb

Int J Obstet Anesth


Adverse side effects and route of administration of opioids in combined spinal-epidural analgesia for labour: a meta-analysis of randomised trials.


Grangier L, Martinez de Tejada B, Savoldelli GL, Irion O, Haller G
Int J Obstet Anesth. 2020 Feb; 41:83-103.
PMID: 31704251.


Studies report an increased risk of maternal and fetal adverse side effects when combined spinal-epidural, rather than standard epidural, analgesia is provided for labour and delivery. Intrathecal opioids used with local anaesthetic in combined spinal-epidural analgesia may be a cause. It is not known whether this is due to the addition of opioid to local anaesthetic in the intrathecal space only or due to concomitant administration into the intrathecal and epidural spaces.