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Papers of the Week

2021 Jan 01

J Clin Neurophysiol



Cortical Spreading Depression Phenomena Are Frequent in Ischemic and Traumatic Penumbra: A Prospective Study in Patients With Traumatic Brain Injury and Large Hemispheric Ischemic Stroke.


Sueiras M, Thonon V, Santamarina E, Sánchez-Guerrero Á, Poca MA, Quintana M, Riveiro M, Sahuquillo J
J Clin Neurophysiol. 2021 Jan 01; 38(1):47-55.
PMID: 31702708.


Spreading depolarization (SD) phenomena are waves of neuronal depolarization, which propagate slowly at a velocity of 1 to 5 mm/minute and can occur in patients with ischemic or hemorrhagic stroke, traumatic brain injury, and migraine with aura. They form part of secondary injury, occurring after spreading ischemia. The purposes of this study were to describe the frequency and characteristics of SD phenomena and to define whether a correlation existed between SD and outcome in a group of patients with TBI and large hemispheric ischemic stroke.