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Papers of the Week

Papers: 2 Nov 2019 - 8 Nov 2019

Human Studies


J Pain Res


Pain symptomology, functional impact, and treatment of people with Neurofibromatosis type 1.


Buono FD, Grau LE, Sprong ME, Morford KL, Johnson KJ, Gutmann DH
J Pain Res. 2019; 12:2555-2561.
PMID: 31692483.


Neurofibromatosis type 1 (NF1) is a neurogenetic disorder affecting 1 in 3000 people worldwide, where individuals are prone to develop benign and malignant tumors. In addition, many people with NF1 complain of pain that limits their daily functioning. Due to the complexity of the disorder, there are few options for treating pain symptoms besides surgery and medications. Moreover, the spectrum of pain symptomatology and treatment, as well as the mechanisms underlying NF1-associated pain, has been understudied.