I am a
Home I AM A Search Login

Papers of the Week

2019 Dec

J Oral Biosci



Dietary constituent genistein inhibits the hyperexcitability of trigeminal nociceptive neurons associated with mechanical hyperalgesia following orofacial inflammation.


Arakawa S, Inoue M, Kinouchi R, Morizumi S, Yamaguchi M, Shimazu Y, Takeda M
J Oral Biosci. 2019 Dec; 61(4):215-220.
PMID: 31669715.


Genistein, a dietary constituent, modulates voltage-dependent and ligand-gated ionic channels, suggesting that it could also attenuate inflammatory hyperalgesia. However, the mechanism underlying how genistein affects inflammation-induced hyperexcitability of nociceptive neurons in vivo remains to be determined. The present study therefore investigated whether administration of genistein could attenuate the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons associated with mechanical hyperalgesia in vivo.