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Papers of the Week

Papers: 2 Nov 2019 - 8 Nov 2019

Human Studies

2020 Feb

Eur J Pain



Fibromyalgia syndrome – a laser-evoked potentials study unsupportive of small nerve fiber involvement.


Van Assche DCF, Plaghki L, Masquelier E, Hatem SM
Eur J Pain. 2020 Feb; 24(2):448-456.
PMID: 31670448.


Fibromyalgia syndrome (FMS) is a chronic pain syndrome characterized by widespread pain and a variety of non-pain symptoms. Central sensitivity phenomena are found consistently in FMS. Additionally, several researchers proclaimed that a subgroup of FMS patients may present with unrecognized peripheral small fiber neuropathy (SFN). Laser-evoked brain potentials (LEP) are considered as a reliable method for the functional assessment of the thermo-nociceptive system, including the evaluation of SFN.