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Papers of the Week

Papers: 2 Nov 2019 - 8 Nov 2019

Animal Studies

2020 Jul




Chronic stress influences nociceptive sensitivity of female rats in an estrous cycle-dependent manner.


Yang C-X, Wang Y, Lu Q, Lian Y-N, Anto E O, Zhang Y, Wang W
Stress. 2020 Jul; 23(4):386-392.
PMID: 31672079.


Exposure to chronic stress can influence nociception and further induce hyperalgesia. Whether stress modulation of pain in female animals occurs in an estrous cycle-specific manner is still unclear. We profiled the changes in nociception (thermal, mechanical, formalin-evoked acute and inflammatory pain) of female Sprague-Dawley rats after treatment with chronic unpredictable mild stress (CUMS) and investigated whether these changes occur in an estrous cycle-dependent manner. The results showed that CUMS female rats exhibited a lower mechanical withdrawal threshold in proestrus and estrus, a longer formalin-evoked licking time in metestrus and diestrus, but no changes in the latency time on the tail-flick test. The present study findings suggest that chronic stress induces mechanical and formalin-evoked acute hyperalgesia of female rats in an estrous cycle-dependent manner.