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Epidural Analgesia (EA) is frequently used as an adjuvant to general anesthesia (GA) for improved post-operative analgesia and reduced rates of cardiac, pulmonary, and renal complications. However, only a few studies have examined EA-GA specifically during open abdominal aortic aneurysm (AAA) repair. The effects of EA-GA specifically during open AAA repair regarding post-operative outcomes are unknown. This study was performed to evaluate post-operative outcomes in patients undergoing open AAA repair with EA-GA versus GA alone.