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Papers of the Week

2019 Sep

J Pharmacopuncture



26-Week Repeated Dose Oral Toxicity Study of KCHO-1 in Sprague-Dawley Rats.


Yang M, Lee S, Wang T, Cha E, Jang J, Kim D, Song B-K, Son I, Kim J, Kang H W, Kim S
J Pharmacopuncture. 2019 Sep; 22(3):192-199.
PMID: 31673451.


KCHO-1(Mecasin), also called Gamijakyakgamchobuja-tang originally, is a combination of some traditional herbal medicines in East Asia. This medicine has been used mainly for alleviating neuropathic pains for centuries in Korean traditional medicine. KCHO-1 was developed to treat pain, joint contracture and muscular weakness in patients with amyotrophic lateral sclerosis. This study was carried out to investigate the chronic toxicity of KCHO-1 oral administration in rats for 26 weeks.