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Papers of the Week

Papers: 26 Oct 2019 - 1 Nov 2019

Animal Studies

2019 Nov

Nat Struct Mol Biol



Editor's Pick

Structural basis of temperature sensation by the TRP channel TRPV3.


Singh AK, McGoldrick LL, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky AI
Nat Struct Mol Biol. 2019 Nov; 26(11):994-998.
PMID: 31636415.


We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo α-to-π transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.