I am a
Home I AM A Search Login

Papers of the Week

Papers: 26 Oct 2019 - 1 Nov 2019

Pharmacology/Drug Development

2019 Oct

Medicine (Baltimore)



Individual opioids, and long- versus short-acting opioids, for chronic noncancer pain: Protocol for a network meta-analysis of randomized controlled trials.


Noori A, Busse JW, Sadeghirad B, Siemieniuk RA, Wang L, Couban R, Juurlink DN, Thabane L, Guyatt GH
Medicine (Baltimore). 2019 Oct; 98(43):e17647.
PMID: 31651885.


Opioids are frequently prescribed for the management of patients with chronic non-cancer pain (CNCP). Previous meta-analyses of efficacy and harms have combined treatment effects across all opioids; however, specific opioids, pharmacokinetic properties (ie, long acting vs short acting), or the type of formulation (ie, immediate vs extended release) may be a source of heterogeneity for pooled effects.