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Papers of the Week

Papers: 26 Oct 2019 - 1 Nov 2019

Human Studies, Pharmacology/Drug Development

2020 Feb

Acta Anaesthesiol Scand



Benefits and harm of paracetamol and ibuprofen in combination for postoperative pain: preplanned subgroup analyses of the multicenter randomized PANSAID trial.


Thybo KH, Hägi-Pedersen D, Wetterslev J, Dahl JB, Jakobsen JC, Pedersen N A, Jakobsen K, Bülow H H, Ibsen L, Overgaard S, Mathiesen O
Acta Anaesthesiol Scand. 2020 Feb; 64(2):245-253.
PMID: 31648374.


The 'Paracetamol and Ibuprofen in Combination' (PANSAID) trial showed that combining paracetamol and ibuprofen resulted in lower opioid consumption than each drug alone and we did not findan increase in risk of harm when using ibuprofen versus paracetamol. The aim of this subgroup analysis was to investigate differences in benefits and harms of the interventions in different subgroups. We hypothesized the intervention effects would differ in subgroups with different risk of pain or adverse events.