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Papers of the Week

2019 Jul

ACG Case Rep J



Isolated Intestinal Ganglioneuroma Mimicking Small Bowel Crohn’s Disease.


Badrinath M, Mandru R, Lowe D, Manocha D, Achufusi T
ACG Case Rep J. 2019 Jul; 6(7):e00114.
PMID: 31620517.


Ganglioneuromas (GNs) are hamartomatous tumors derived from the autonomic nervous system. GNs are frequently associated with neurofibromatosis-1 and multiple endocrine neoplasia type 2b and commonly present with constipation, abdominal pain, weight loss, obstruction, and gastrointestinal bleeding. We report a 40-year-old man with symptoms of chronic abdominal pain, weight loss, and diarrhea for 1 year. Imaging was suggestive of thickening of ileal wall with a stricture, and subsequent biopsy revealed intestinal GN. To our knowledge, this is the first case report of an isolated intestinal GN masquerading as Crohn's disease.