I am a
Home I AM A Search Login

Papers of the Week

Papers: 19 Oct 2019 - 25 Oct 2019

Human Studies, Pharmacology/Drug Development


2019 Oct 17

BMC Neurol



Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication-overuse headache.


Pellesi L, Bellei E, Guerzoni S, Cainazzo M M, Baraldi C, Monari E, Pini L A
BMC Neurol. 2019 Oct 17; 19(1):239.
PMID: 31623575.


Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several proteins have been found at high concentrations in the urine of MOH patients and in the serum of rats with neuropathic pain. The aim of this study was to compare the serum levels of lipocalin-type Prostaglandin D2 synthase (L-PGDS), Vitamin D-binding protein (VDBP), apolipoprotein E (APOE) and apolipoprotein A1 (APOA1) in MOH patients and healthy individuals, further exploring their relationship with cutaneous pain thresholds (CPTs) in the territories innervated by the trigeminal nerve.