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Papers of the Week

2020 Jan 01

Int J Radiat Oncol Biol Phys



Minocycline Reduces Chemoradiation-Related Symptom Burden in Patients with Non-small Cell Lung Cancer: A Phase II Randomized Trial.


Wang X S, Shi Q, Mendoza T, Lin S, Chang JY, Bokhari RH, Lin H-K, Garcia-Gonzalez A, Kamal M, Cleeland CS, Liao Z
Int J Radiat Oncol Biol Phys. 2020 Jan 01; 106(1):100-107.
PMID: 31627177.


In patients with non-small cell lung cancer (NSCLC), concurrent chemoradiation therapy (CRT) exacerbates a cluster of difficult-to-manage symptoms, especially cancer-related fatigue. Minocycline is a readily available, low-cost antibiotic with anti-inflammatory properties. We conducted a phase II randomized, double-blinded, placebo-controlled trial to investigate the effect of minocycline in reducing CRT-symptom burden in NSCLC.