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Papers of the Week

Papers: 12 Oct 2019 - 18 Oct 2019

Animal Studies, Pharmacology/Drug Development

2019 Jan-Dec

Mol Pain


Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain.


Tsymbalyuk S, Smith M, Gore C, Tsymbalyuk O, Ivanova S, Sansur C, Gerzanich V, Simard M MJ
Mol Pain. 2019 Jan-Dec; 15:1744806919886503.
PMID: 31615323.


The anti-seizure racetams may provide novel molecular insights into neuropathic pain due to their unique mechanism involving synaptic vesicle glycoprotein 2A (SV2A). Anti-allodynic effects of levetiracetam (LEV) have been shown in animal models of neuropathic pain. Here, we studied the effect of brivaracetam (BRV), which binds to SV2A with 20-fold greater affinity, and has fewer off-target effects.