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Papers: 12 Oct 2019 - 18 Oct 2019
Animal Studies, Pharmacology/Drug Development
2019 Jan-Dec
Mol Pain
15
The anti-seizure racetams may provide novel molecular insights into neuropathic pain due to their unique mechanism involving synaptic vesicle glycoprotein 2A (SV2A). Anti-allodynic effects of levetiracetam (LEV) have been shown in animal models of neuropathic pain. Here, we studied the effect of brivaracetam (BRV), which binds to SV2A with 20-fold greater affinity, and has fewer off-target effects.